Corning® TransportoCells™ Human BCRP Vesicle, 5 mg/ mL, 0.5 mLProduct Number 453804
This is suggested replacement for 453271).
Corning TransportoCells HEK293-derived ABC transporter vesicles express more human-like transporter proteins within the human cellular membrane. These HEK membrane vesicles have demonstrated a significantly higher uptake activity and lower background as compared with traditional insect cell-derived vesicles. The validated vesicle model could potentially improve in vitro to in vivo prediction because of the more in vivo-like recombinant proteins and membrane composition. The products can be used for drug transporter phenotyping, drug-drug interaction and toxicity studies, drug clearance prediction, and mechanistic studies of drug transport.
- Contain more in vivo-like recombinant proteins and membrane composition, thus providing the potential for a better in vitro to in vivo correlation
- Demonstrate a robust dynamic range with significantly higher uptake activity and lower background than insect cell expression systems
- Has been fully validated for substrate specificity, transporter kinetics, and inhibition profiles
- Support the USFDA, EMA, and ITC recommendations for the identification of drug transporters and transporter drug-drug interaction studies
This product is non-returnable. If you have any questions, please contact us immediately.
$701.44 per each
Less than 10 in Stock
|Qty./Pk||1 / Pk|
|Qty./Cs||1 / Ea|
|Protein Concentration||5 mg/mL|
|Shelf Life||5 years|