The development and normal functioning of cells depends on interactions with molecules in their micro-environment. The major classes of molecules that regulate cellular development and function include growth and differentiation factors, cell adhesion molecules, and the components of the extracellular matrix (ECM). The ECM is composed of a number of different macromolecules whose structural integrity and functional composition are important in maintaining normal tissue architecture, in development and in tissue-specific function. The ECM exerts influences on behavior (adherence, spreading, differentiation, and migration) and the pattern of gene expression of the cells in contact with it. The ECM, however, is not static but changes during both normal development and in tissue repair and regeneration and is intimately involved in both normal biological function and response to injury.
Corning BioCoat cultureware is a unique line of tissue culture vessels with various ECM components or synthetic substrates applied to vessel surfaces by a proprietary manufacturing process to create more physiological relevant in vitro models. Corning BioCoat cultureware promotes cell attachment, spreading, growth, and differentiation of a variety of primary cells and cell lines in serum-free or serum-containing cultures.
Enzyme Linked Immunosorbent Assay (ELISA) is accurate, highly sensitive, and specific for identifying protein species. ELISA microplates enable a common laboratory procedure to be carried out on multiple samples simultaneously. Popular formats include 96-well microplates, 384-well microplates, and 8-well strips.
Enzyme Linked Immunosorbent Assay (ELISA) is accurate, highly sensitive, and specific for identifying protein species. ELISA microplates enable a common laboratory procedure to be carried out on multiple samples simultaneously. Popular formats include 96-well microplates, 384-well microplates, and 8-well strips.