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Corning® Gentest™ ABC Transporter Vesicles

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Corning TransportoCells HEK293-derived ABC transporter vesicles express more human-like transporter proteins within the human cellular membrane. These HEK membrane vesicles have demonstrated a significantly higher uptake activity and lower background as compared with traditional insect cell-derived vesicles. The validated vesicle model could potentially improve in vitro to in vivo prediction because of the more in vivo-like recombinant proteins and membrane composition. The products can be used for drug transporter phenotyping, drug-drug interaction and toxicity studies, drug clearance prediction, and mechanistic studies of drug transport.

  • Contain more in vivo-like recombinant proteins and membrane composition, thus providing the potential for a better in vitro to in vivo correlation
  • Demonstrate a robust dynamic range with significantly higher uptake activity and lower background than insect cell expression systems
  • Has been fully validated for substrate specificity, transporter kinetics, and inhibition profiles
  • Support the USFDA, EMA, and ITC recommendations for the identification of drug transporters and transporter drug-drug interaction studies

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Products

Product Number Product Name パック入数 ケース入数 ブランド Price Unit Size
453800 トランスポートセル HEK293由来 ネガティブコントロールベシクル, 0.5mL   1 / パック     1 / Ea     Corning®   ¥ 70,000 per each
453801 トランスポートセル HEK293由来 ヒトMDR1/p-gpベシクル, 0.5mL   1 / パック     1 / Ea     Corning®   ¥ 85,000 per each
453802 Corning® TransportoCells™ベシクルBSEPベジクル、5 mg/mL、0.5 mL   1 / パック     1 / Ea     Corning®   ¥ 85,000 per each
453803 Corning® TransportoCells™ヒトMRP2ベシクル、5 mg/mL、0.5 mL   1 / パック     1 / Ea     Corning®   ¥ 85,000 per each
453804 Corning® TransportoCells™ヒトBCRPベシクル、5 mg/mL、0.5 mL   1 / パック     1 / Ea     Corning®   ¥ 85,000 per each
453805 Corning® TransportoCells™ヒトMRP3ベシクル、5 mg/mL、0.5 mL   1 / パック     1 / Ea     Corning®   ¥ 85,000 per each
453806 Corning® TransportoCells™ヒトMRP4ベシクル、5 mg/mL、0.5 mL   1 / パック     1 / Ea     Corning®   ¥ 85,000 per each