Corning® Matrigel® Growth Factor Reduced (GFR) Basement Membrane Matrix, Phenol Red-free, LDEV-free, 10 mL

A complex set of biophysical (e.g., topography, stiffness, viscosity, porosity) and biochemical (e.g., nutrients, matrix composition, cell-matrix interactions) cues control cell biology1. In order to mimic the in vivo cellular behavior for understanding basic biology, tissue engineering and regenerative medicine applications, it is imperative to better elucidate and control these interactions.

A complex set of biophysical (e.g., topography, stiffness, viscosity, porosity) and biochemical (e.g., nutrients, matrix composition, cell-matrix interactions) cues control cell biology1. In order to mimic the in vivo cellular behavior for understanding basic biology, tissue engineering and regenerative medicine applications, it is imperative to better elucidate and control these interactions.

Formation of gastrointestinal organoids derived from human induced pluripotent stem cells (hiPSC) in Corning® 96-well spheroid microplates in combination with Corning Matrigel® matrix, resulting in a single intestinal organoid in each well.

Formation of gastrointestinal organoids derived from human induced pluripotent stem cells (hiPSC) in Corning® 96-well spheroid microplates in combination with Corning Matrigel® matrix, resulting in a single intestinal organoid in each well.

In this article, we demonstrate use of Corning Matrigel matrix for organoid culture to maintain human intestinal organoids (HIO) for multiple passages.

In this article, we demonstrate use of Corning Matrigel matrix for organoid culture to maintain human intestinal organoids (HIO) for multiple passages.

With the recent COVID-19 pandemic, there has been an increase in publications using human airway epithelial (HAE) cells to model SARS-CoV-2 infectivity, pathogenesis and treatment. These include the use of Corning® Transwell® permeable supports to create air-liquid interface (ALI) epithelium cultures and Corning Matrigel® to generate airway tissue-like organoids. Both ALI and organoid models provide greater physiological relevance versus conventional cell culture and are proving to be useful tools in COVID-19 research. This Application Note discusses 3D cell culture models in coronavirus research and includes a summary of recently published articles related to COVID-19.

With the recent COVID-19 pandemic, there has been an increase in publications using human airway epithelial (HAE) cells to model SARS-CoV-2 infectivity, pathogenesis and treatment. These include the use of Corning® Transwell® permeable supports to create air-liquid interface (ALI) epithelium cultures and Corning Matrigel® to generate airway tissue-like organoids. Both ALI and organoid models provide greater physiological relevance versus conventional cell culture and are proving to be useful tools in COVID-19 research. This Application Note discusses 3D cell culture models in coronavirus research and includes a summary of recently published articles related to COVID-19.

The Corning Matribot bioprinter exhibited cell-friendly dispensing performance similar to that of the manual dispensing operation. The culture dispensed by the Corning Matribot bioprinter were suitable for further molecular and protein analysis as well as downstream applications including high throughput drug screening.

Use the Corning® selection guide to help you choose the best surface for your application and cell type.

Corning マトリゲル基底膜マトリックスは上皮様細胞などの基質依存性細胞の接着や分化に有効で、細胞の 3 次元培養、浸潤アッセイ、肝細胞を用いた代謝・毒性研究、血管新生、腫瘍細胞の移植などいろいろなアプリケーションに利用されています。ここでは、マトリゲル基底膜マトリックスをマウスの体内に注入して用いる、血管新生や腫瘍細胞の移植に役立つ情報をご紹介いたします。

マトリゲル基底膜マトリックスの解凍方法からアプリケーションノート、Q&Aまでをまとめた技術資料集です。関連製品も載っています。

Key considerations for working with MSCs, iPSCs, and NSCs through different stages of the workflow.

Cells behave more naturally when their microenvironment mimics in vivo conditions. But with these three different models — spheroids, organoids, and tissue models — how do you choose?

Cellular motility is when cells move from place to place in response to chemical signals. Many cellular functions rely on that movement, including cell differentiation, wound repair, embryonic development, angiogenesis, and tumor metastasis.

細胞外基質（ECM）タンパク質は、in vivo（生体内）に近い環境での培養細胞の接着、増殖、挙動をサポートするため、適切な製品を選ぶことが重要です。

オルガノイド培養への投資は、より正確な前臨床試験をもたらし、薬物試験の成功率改善につながります。 新薬探索において、オルガノイドは、開発の効率とスピードを維持しながら前臨床新薬開発における生物学的な関連性と正確性を改善します。

Corning マトリゲル基底膜マトリックスが研究者に選ばれてるのには、5つのたしかな理由があります。

Create in vivo-like models with Corning with our in-depth knowledge, expertise, and hand-on assistance in 3D cell culture. Accelerate your next discovery with our products and resources for 3D cell culture environments.

35 年以上の実績と、13,000 以上の引用文献数。オリジナルとしての信頼と品質。 コーニングは、様々なアプリケーションで広がりをみせるマトリゲル基底膜マトリックスの需要を支えるため、生産量を大幅に増やしました。厳格な製造プロセスへのこだわりを維持し、コーニングの高品質な製品をお届けします。

研究者のための使用法ガイド オルガノイド培養において考慮すべきベストプラクティス、およびCorning マトリゲル基底膜マトリックスやその他の製品を使用して研究をサポートする方法について詳しく説明します。

科学研究で最も広く使用されている細胞外基質であるCorning マトリゲル基底膜マトリックスに関する事実、ヒント、専門家のアドバイスをまとめました。

An informative list of recent publication on 3D organoids that uses Matrigel.

An informative list of recent publication on 3D organoids that uses Matrigel.

Corning Matrigel basement membrane matrix is effective for the attachment and differentiation of both normal and transformed anchorage-dependent epithelioid and other cell types.

Corning Matrigel basement membrane matrix is effective for the attachment and differentiation of both normal and transformed anchorage-dependent epithelioid and other cell types.

コーニングのクラウドベースの自動セルカウンターは、従来、2D 培養細胞を早く正確に測定することに重点を置いてきました。今回、オルガノイドカウントのアプリケーションを追加することで、大きく発展している3D 培養にもコーニングの自動細胞カウント技術を拡大しました。

Corning Matrigel matrix is a commonly utilized tool for creating three-dimensional (3D) spheroids and organoids. Often the recovery of the 3D structures from the matrix is required for downstream applications such as DNA extraction, histology, or immunostaining. Here we provide guidelines for recovering 3D structures that are embedded in Matrigel matrix.

Updated November 21, 2024

細胞と表面には相性があり、適した表面を選択することが重要です。コーニングでは、細胞の接着や増殖、分化、移動などをサポートする、動物やヒト、合成由来の基質を幅広く提供しています。本冊子では、各種製品の特長とラインナップ、細胞別セレクションリストをまとめました。

Corning®、Corning BioCoat™、Corning PureCoat™、PYREX® 製品の総合カタログです。

Falcon®、Corning® BioCoat™、Corning PureCoat™ 製品の総合カタログです。