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Corning® Gentest™ ABC Transporter Vesicles

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Corning TransportoCells HEK293-derived ABC transporter vesicles express more human-like transporter proteins within the human cellular membrane. These HEK membrane vesicles have demonstrated a significantly higher uptake activity and lower background as compared with traditional insect cell-derived vesicles. The validated vesicle model could potentially improve in vitro to in vivo prediction because of the more in vivo-like recombinant proteins and membrane composition. The products can be used for drug transporter phenotyping, drug-drug interaction and toxicity studies, drug clearance prediction, and mechanistic studies of drug transport.

  • Contain more in vivo-like recombinant proteins and membrane composition, thus providing the potential for a better in vitro to in vivo correlation
  • Demonstrate a robust dynamic range with significantly higher uptake activity and lower background than insect cell expression systems
  • Has been fully validated for substrate specificity, transporter kinetics, and inhibition profiles
  • Support the USFDA, EMA, and ITC recommendations for the identification of drug transporters and transporter drug-drug interaction studies

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Product Number Product Name Qty./Pk Qty./Cs Brand Price Unit Size
453801 Corning® TransportoCells™ Human MDR1 Vesicle, 5 mg/ mL, 0.5 mL   1 / Pk     1 / Ea     Corning®   £542.86 per each