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Corning® Supersomes™ Human CYP2C8 + Oxidoreductase, 1.0 nmol

Product Number 456212
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Recombinant enzyme prepared from insect cells infected with baculovirus containing desired cDNAs

CYP2C8 is involved in the metabolism of several drug substrates such as the anti-cancer drug paclitaxel (TAXOL®), amodiaquine, torsemide, cervastatin, and repaglinide. Paclitaxel and amodiaquine are recommended probe substrates for CYP2C8. Endogenous CYP2C8 substrates include retinoic acid and arachidonic acid.

CYP2C8*3 is the major variant allele in Caucasian populations. The mutation results in significantly lower activity for certain CYP2C8 substrates relative to the wild-type enzyme (e.g., paclitaxel and arachadonic acid metabolism). In African-American populations the major allelic variant is CYP2C8*2. In Asian populations neither allelic variant is prevalent.

CYP2C8*3 and CYP2C9*2 allelic variants are linked (96% of 2C9*2/*2 are 2C8*3/*3 and 85% of 2C8*3/*3 are 2C9*2/*2).

  • Contains Human Oxidoreductase, but not cytochrome b₅
  • Available size: 1.0 nmole P450 in 0.5 mL
  • Protein concentration: Available in batch data sheet. Contact Corning Scientific support to obtain the information.



This product is non-returnable. If you have any questions, please contact us immediately.


$238.48 per each

In Stock

Details
Product Number   456212
Qty./Pk   1 / Pk  
Qty./Cs   1 / Ea  
Brand   Corning®  
Size   1 nmol  
Species   Human  
Enzyme Type   P450  
Protein Concentration   Lot-dependent  
Storage   -80°C  
Cellular Location   Microsome  
Specifications Documents