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 IMPORTANT UPDATE:  Some items may be delayed in shipping or out of stock due to extremely high demand.

Corning® Supersomes™ Human CYP2A6 + Oxidoreductase + b5, 0.5 nmol

Product Number 456254

Recombinant enzyme prepared from insect cells infected with baculovirus containing desired cDNAs

CYP2A6 is the major coumarin 7-hydroxylase, which is a probe substrate activity for CYP2A6 in HLMs. CYP2A6 is the primary enzyme for nicotine clearance catalyzing the initial C-oxidation and subsequent cotinine hydroxylation step. CYP2A6 catalyzes the bioactivation of Tegafur to 5-fluorouracil, an anticancer agent. CYP2A6 is inhibited by high ionic strength buffers. CYP2A6 is a low affinity enzyme for the activation of N-nitrosodimethylamine and a relatively high affinity enzyme for the activation of N-nitrosodiethylamine CYP2A6 is a low affinity enzyme for the activation of aflatoxin B₁ and is also capable of activating benzo(a)pyrene and the tobacco smoke-derived nitrosamine, NNK.

  • Contains Human Oxidoreductase and cytochrome b₅
  • Available size: 0.5 nmole P450 in 0.5 mL
  • Protein concentration: Available in batch data sheet. Contact Corning Scientific support to obtain the information.

This product is non-returnable. If you have any questions, please contact us immediately.

$176.99 per each

In Stock

Product Number   456254
Qty./Pk   1 / Pk  
Qty./Cs   1 / Ea  
Brand   Corning®  
Size   0.5 nmol  
Species   Human  
Enzyme Type   P450  
Protein Concentration   Lot-dependent  
Storage   -80°C  
Cellular Location   Microsome  
Specifications Documents