Corning Gentest ABC transporter inside-out vesicles are used in in vitro direct uptake assays to evaluate whether a drug candidate is a substrate or inhibitor for transporters. This information can help to predict the interactions between drug compounds and efflux transporters. ABC transporter vesicles are an ideal transporter model over cell-based assays for compounds unable to penetrate the plasma membrane by simple diffusion.
- Prepared from recombinant baculovirus-infected insect cells
- Direct measurement of transporter-mediated drug uptake
- Use in drug uptake assays for radiolabeled or non-radiolabeled compounds
Corning also offers transporter vesicle kits to use with the vesicle products. The kits contain all necessary buffers and chemicals for performing 200 assays, providing convenience and reducing the time needed for reagent preparation.
Arg = Arginine.