Fetal Bovine Serum (FBS) is a time tested, universal supplement used in cell culture. It provides many compounds that have been shown to satisfy specific metabolic requirements for the culture of cells, including hormones, growth factors, cell attachment factors, pH buffer, protease inhibitors, vitamins, minerals, lipids, and a variety of undefined components. Fetal bovine serum also protects against toxic effects associated with pH change, the presence of heavy metal ions, endotoxin, and proteolytic activity.
Corning offers a wide variety of fetal bovine serum (FBS) options to satisfy multiple applications. Our FBS is a perfect complement to our classical and custom cell culture media products.
Learn more about our custom serum options.
Sera Processing
Using industry leading techniques, blood is aseptically collected at abattoirs, centrifuged to isolate the serum and immediately frozen for testing and further processing. The raw sera is then true pooled and is triple 0.1 micron sterile filtered with a Sterility Assurance Level (SAL) of 10-3. Every lot of Corning FBS then must pass USP <71> and EP 2.6.1 sterility testing, growth promotion testing, as well as test negative for mycoplasma and number of industry-monitored viruses. Authenticity of the fetal bovine serum is verified using industry leading measurements of Gamma-Glutamyl Transferase and Corning’s high internal standard of ≤ 10 IU/L. Additional testing includes endotoxin, hemoglobin, pH, osmolality, total protein, and a biochemical profile that contains various metals, proteins, hormones and other metabolites.
EDQM Certificates of Suitability
Fetal Bovine Serum, United States Origin
This product has been granted a Certificate of Suitability, R0-CEP 2018-271, by the European Directorate for the Quality of Medicines (EDQM) certifying that the product meets the criteria described in the current version of the monograph no. 1483 of the European Pharmacopoeia “Product with risk of transmitting agent of animal spongiform encephalopathies.”
Supply Chain
Our vertically integrated fetal bovine serum supply chain, from collection to scientist, allows us to provide a consistent supply of FBS.
Origin Statement
Corning’s premium FBS is only collected from government approved abattoirs in the United States, Australia, and New Zealand. All premium fetal bovine serum is derived from fetuses collected from healthy bovine cows and heifers that have passed ante and post mortem inspection and were found free of contagious diseases. These countries are recognized by the World Organization for Animal Health as having negligible risk of Bovine Spongiform Encephalopathy and being free from foot and mouth disease.
Corning’s regular FBS is derived from government registered facilities in North, Central, and South America and countries that are USDA safety tested for import into the United States. All regular fetal bovine serum is derived from fetuses collected from healthy bovine cows and heifers that have passed ante and post mortem inspection and were found free of contagious diseases. The material was exported from the country of origin accompanied with a Veterinarian Health Certificate.